Name: γ－aminobutyric acid powder (GABA)
Brand: Joyous Pellets Supplement raw materials, cosmetic ingredients, weight
Availability: InStock
Rating: 5 (1 reviews)

Gamma-aminobutyric acid is a compound with the chemical formula C₄H₉NO₂, also known as γ-aminobutyric acid, or GABA for short. It is an amino acid. Gamma-aminobutyric acid. GABA is an important inhibitory neurotransmitter in the central nervous system. It has Good water solubility and thermal stability. Studies have shown that consuming a certain amount of GABA has physiological effects such as improving the body's sleep quality and lowering blood pressure.

Product Name

γ－aminobutyric acid (GABA)

Specification

99%

Appearance

White crystalline powder

CAS No

56-12-2

Chemical Formula

C₄H₉NO₂

Packaging

25kg cardboard drum

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Desciption

Product information
What is γ-aminobutyric acid powder?
γ-Aminobutyric acid is an amino acid that is widely found in vertebrates, plants and microorganisms. Gamma-aminobutyric acid, GABA is an important central nervous system inhibitory neurotransmitter. As a small molecular weight non-protein amino acid, GABA is safe to eat and can be used in the production of beverages and other foods. It has physiological effects such as improving the body's sleep quality and lowering blood pressure.
Theoretically, there are three sources of GABA, namely natural sources, fermentation sources and synthetic sources. However, in fact, only synthetic and fermentation sources can be used on a large scale by manufacturers.
Joyous γ－aminobutyric acid powder powder specification

Terms	Standard	Terms	Standard
Product Name	γ－aminobutyric acid	Appearance	White crystalline powder
Assay	98%	Other Name	GABA
Total Heavy Metals	≤10 ppm	Ash	≤2%
As	≤0.5ppm	Total Plate Count	≤750 cfu/g
Pb	≤0.5ppm	Yeast and Mold	≤100 cfu/g
Cd	≤0.5ppm	Coliforms	Negative
Hg	≤0.1ppm	E.Coli	Negative
Packing	Pack in 25kgs paper-drums, inner by double plastic bag	Shelf life	24 months under the above condition, and in its original package

Preparation methods of several sources of γ-aminobutyric acid powder (GABA)
chemical synthesis
The more important chemical synthesis mainly includes the following types: The first one uses potassium phthalimide and γ-chlorobutyric acid or butyrolactone as raw materials for making GABA. The final product obtained after violent reaction and hydrolysis is GABA; the second is to use pyrrolidone as the initial raw material, and hydrolyze it through calcium hydroxide and ammonium bicarbonate, and finally open the ring to obtain the product GABA; the third is to use butyric acid and ammonia as the raw materials of GABA, The fourth method is to use propylamine and formic acid to synthesize GABA through the glow discharge method; the fifth method is to prepare GABA by using methyl bromoacetate and ethylene as The raw materials are polymerized to obtain 4-bromobutyric acid methyl ester, and the final product after ammonolysis and hydrolysis is GABA. The chemical synthesis methods of GABA all have the disadvantages that the reaction is not easy to control and the cost is relatively high.
plant enrichment method
The plant enrichment method is a newly developed synthetic extraction and purification technology. It uses plants with higher GABA content to separate and extract, thus producing GABA products that are both cheap and high in purity. There are two main ways to obtain GABA from plants: one is the solvent extraction and purification method, and the other is the column separation preparation method.
(1) Solvent extraction method
The solvent extraction method uses water or alcohol as the extractant of GABA. According to the principle of different solubility and distribution coefficient of plants in water or alcohol, GABA is extracted into water or alcohol, and after repeated filtration and purification, the plant can be completely isolated. Most of the GABA is extracted. [2]
(2) Column separation preparation method
Column separation preparation method, also called column chromatography, is a method that uses the principle that the components in different mixtures have different distribution coefficients in the solid-liquid phase to perform elution separation and other subsequent operations. Its broad classification should be Belongs to chromatography. Chromatographic columns generally use resin, silica gel or activated carbon as filling materials.
microbial fermentation
The microbial fermentation method is to select excellent, stable, non-toxic and harmless strains, and use these strains to prepare and produce GABA during the growth and reproduction process. Although this method has strict environmental requirements and high equipment requirements, the GABA produced by this method can be used as a natural food additive. The use of microbial fermentation production is one of the earliest and most extensive production methods in the food industry. The earliest microorganism used was Escherichia coli, whose decarboxylase can be used to produce GABA. However, due to its own safety hazards, it has been It cannot be used directly in the production of medicine or food.
With the development of science and technology, green food has attracted more and more attention. Later, scientific researchers discovered that microorganisms such as lactic acid bacteria, yeast, and Aspergillus can be used to replace E. coli and catalyze the production of GABA. Moreover, at a lower cost, it also has the advantages of high output and good safety. This method has gradually developed towards industrial production. This is also the fermentation method used by Joyous GABA.
Safety and dosage of γ-aminobutyric acid powder (GABA)
The European Food Safety Authority (EFSA) allows the addition of GABA to food and stipulates that the upper limit of dietary intake of GABA is 550 mg/d. The U.S. Food and Drug Administration (FDA) points out that GABA is safe to be added to food based on toxicology test results. The scope includes beverages, coffee, tea and chewing gum, etc. It is not allowed to be added to baby food, meat products or meat-containing products. Announcement No. 12 of the Ministry of Health of China in 2009 states that the intake of GABA shall not exceed 500mg/d, and its use scope is beverages, cocoa products, chocolate and beverages, candies, baked goods and puffed foods. It cannot be added to baby food.
GABA has been found in many animals, plants and microorganisms. It was first discovered in potato tubers in 1949, and was found in the central system of mammals in 1950. It is also considered to be a component of mammals, insects or certain organisms. Neural inhibitors in the nervous system of some parasitic worms have an important impact on the excitability of neurons. Research has found that GABA is an active amino acid that plays an important role in the energy metabolism of the human brain. It activates glucose metabolism in the brain, promotes acetylcholine synthesis, lowers blood ammonia, anti-convulsants, lowers blood pressure, improves brain function, stabilizes the mind, and promotes growth. Hormone secretion and other physiological functions.
Mouse experiment 1:
Study the effect of oral administration of gamma-aminobutyric acid on improving sleep in mice. Methods: The mice were divided into three batches A, B, and C for the experiment. Each batch had five groups, which were the negative control group, the positive control group, and the low, medium, and high-dose groups. Gamma-aminobutyric acid (50, 100, 150 mg/kg) for 30 days, and four sleep efficacy evaluation experiments were conducted. Results: Oral administration of medium and high doses of γ-aminobutyric acid can prolong sleep time and increase the number of animals falling asleep at subthreshold doses, but cannot shorten sleep latency. There was no direct sleep effect in each group. Conclusion: Under the conditions of this experiment, γ-aminobutyric acid Butyric acid can improve sleep when taken orally.
Mouse experiment 2:
GABA-rich yogurt (80 mg/kg) and 160 mg/kg dose groups significantly increased the sleep sleep rate of mice from 0 to 60% (p<0.05); the GABA-rich yogurt (80 mg/kg) group could shorten the sleep duration of mice. It was significantly extended from 43.40 min to 156.20 min (p<0.05); in the insomnia experiment, compared with the insomnia model group, GABA-rich yogurt could significantly increase the contents of inhibitory amino acids GABA and Gly in the brain tissue of insomnia mice (p<0.05 ), the GABA content rose to 1.10 ng/mL, and the Gly content rose to 28.78 ng/mL. The results of this study show that GABA-rich yogurt can effectively extend the sleep duration of ICR mice and improve the insomnia state of mice. The mechanism is related to the increase in The content of the inhibitory transmitters GABA and Gly in the mouse brain is related.
A new form of γ-aminobutyric acid powder (GABA)
When traditional raw material functions have been skillfully used by brand owners, and we are unable to seize the existing market, Joyous has developed brand-new controlled-release granules for better absorption and utilization (higher bioavailability), and more It is in the form of safe and easy-to-use pellets. For details, please see GABA sustained release pellets. It has a very uniform and good-looking appearance. The color can be customized. The very powerful controlled release technology ensures bioavailability. The new protective dosage form makes the product itself safer and more stable. , making customers who take it healthier. Welcome to consult at any time in the lower right corner, we are online at any time.
Package and delivery

Delivery
1-80kg	80-300kg	More than 300kg
More suitable for express transportation, door-to-door	More suitable for air transportation,airport-to-airport	More suitable for ocean transportation,port-to-port
7-10 days for delivery time	3-4 days for delivery time	20-40 days for delivery time

What service we can provide
Joyous Health provides aminobutyric acid powder powder OEM services. We can customize formulas for customers, private labels, capsules, tablets, soft capsules and sachets, low MOQ, which is suitable for direct sales by brands. Our OEM product shipping channels are stable and delivery times are fast and worthy of customers' trust, we have served more than 300 brands.

Joyous Health Factory information and certifications
Xi'an Joyous Health Biotechnology Co., Ltd. was established in 2011. Over the past 12 years, Joyous Health has obtained ISO 9001, FDA, ISO 22000, and GMP certifications.
Joyous Health has an advanced laboratory to control quality, so that each batch of products undergoes strict testing, and has professional R&D personnel to provide customized product services.
For more details please click here

Where to buy γ-aminobutyric acid powder（GABA） powder?
We offer the best GABA powder at the most competitive price. γ-aminobutyric acid Powder bulk and wholesale powder have been 3rd lab-tested and verified for both product purity and identity.
We also provide γ-aminobutyric acid powder in bulk order or wholesale according to client needs. Just submit the requirements in the bottom form, we will reply soon!

Contacts: Faith Feng
Email:faith@joyouspellets.com
Tel and Whatsapp:+86 17391747738

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Contact: Xi'an international enterprise center B building, Fengcheng 4 road, Xi'an City, Shaanxi province, China; info@joyouspellets.com; +86 17391747738

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